Negative Symptom and Cognitive Deficit Treatment Response in Schizophrenia

Cognitive differences between deficit and non-deficit schizophrenia

Deficit versus negative syndrome in schizophrenia: prediction of attentional impairment.

Findings on neuropsychological associates of the negative syndrome of schizophrenia have been inconsistent. The "deficit syndrome," a reconceptualization of the negative syndrome, was developed in part to address this inconsistency. The purpose of this study was (1) to replicate previous findings relating the deficit syndrome to impairment of certain kinds of attentional abilities, and (2) to c...

Treatment-Responsiveness of Negative Symptoms in Schizophrenia: A double-blind placebo-control clinical trial

Background: The negative symptoms of schizophrenia remain a major clinical challenge. Nortriptyline is a serotonin and noradrenalin reuptake inhibitor and belongs to secondary amine tricycles. The aim of this study is to evaluate the effect of nortriptyline on the negative symptoms of schizophrenia. Methods: This study is a six-week randomized placebo-control trial of nortriptyline or placebo a...

Efficacy of Risperidone Augmentation with Ondansetron in the Treatment of Negative and Depressive Symptoms in Schizophrenia: A Randomized Clinical Trial

Background: Given the potential role of the 5-hydroxytryptamine-3 receptor in the pathogenesis of schizophrenia, this study was performed to determine whether ondansetron plus risperidone could reduce the negative and depressive symptoms in patients with treatment-resistant schizophrenia.Methods: In a double-blinded, placebo-controlled, randomized trial (IRCT registration # 201112125280N7), in ...

Evaluating the Efficacy of Vitamin D Add-on Therapy on Treatment of Positive, Negative and Cognitive Symptoms in Patients with Chronic Schizophrenia; A Double Blind Clinical Trial

Background: Vitamin D can be effective in treating some symptoms of schizophrenia, and with better control of vitamin D levels and supplementation, there is a potential for reducing this disease. But due to small number of studies, more studies are needed in this area. The aim of this study was to determine the efficacy of vitamin D as an adjunct to the positive, negative, and cognitive symptom...